Lonely delivery man Joseph falls in love with an alcoholic prostitute named Karen, who frequents one of the stops along his route. Though they soon become friends, Joseph is unable to figure out what makes the very-guarded Karen tick. While Karen drowns the sorrows of her mysterious past, keeping him at bay, Joseph remains committed to winning her affection, resorting to extreme measures in his search for the key to her heart. Embarking on a dark journey with a mystical relic -a 'hand of glory,' whose legend purports the ability to unlock any door- Joseph soon discovers that such feats come at a dire price.
