Natasha O'Keeffe
- Born
- 1 December 1986 (39 years)
- Place of birth
- Brighton, East Sussex, England, UK
- Gender
- Female
Natasha Dervill O'Keeffe (born 1 December 1986) is a British actress. She is known for her roles as Abbey in the E4 series Misfits (2012–2013), Fedora in the ITV series Jekyll and Hyde (2015), Emilia Ricoletti in the Sherlock special "The Abominable Bride" (2016), and Lizzie Shelby in the BBC series Peaky Blinders (2013–2022).
